Drug'dna Interaction Protocols

Experimental scientists describe the techniques they have perfected in their laboratories to illuminate and explore drug-DNA interactions. These reproducible methods involve sequence recognition properties and the physical approaches for measuring the strength of interaction and mode of binding of drugs to DNA. These interactions are also examined from a cellular perspective and for their usefulness as therapeutic agents. The protocols will be useful to new investigators who need the kind of detailed experimental and ... Read More

Experimental scientists describe the techniques they have perfected in their laboratories to illuminate and explore drug-DNA interactions. These reproducible methods involve sequence recognition properties and the physical approaches for measuring the strength of interaction and mode of binding of drugs to DNA. These interactions are also examined from a cellular perspective and for their usefulness as therapeutic agents. The protocols will be useful to new investigators who need the kind of detailed experimental and technical information often omitted from scientific papers, as well as to established workers who wish to expand their repertoire of experimental techniques or to improve their existing techniques. Read Less