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Alexander Disease: A Guide for Patients and Families - Messing, Albee, and Verkhratsky, Alexei, Professor (Editor), and Parpura, Vladimir (Editor)
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This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord. Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood. ...

Alexander Disease: A Guide for Patients and Families 2017, Morgan & Claypool, San Rafael

ISBN-13: 9781615047581

Trade paperback