Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer

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This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein-protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments ...

Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of Pac3 Homodimer 2016, Springer

ISBN-13: 9784431562870

Softcover Reprint of the Origi edition

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Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer 2015, Springer Verlag, Japan, Tokyo

ISBN-13: 9784431554462

2015 edition

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