The Molecular Biology of Paget S Disease


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The osteoclasts in Paget's disease are abnormal both in num- ber and size and show nuclear inclusions as well as cytoplasmic inclusions that suggest a viral etiology for Paget's disease. Use of in vitro model systems for examining osteoclast physiology in Paget's disease has shown that these cells have an increased rate of formation, express high levels of IL-6, IL-6 receptor, and NF-IL-6, as well as most recently, the c-FOS protooncogene. 31 The precur- sors for these pagetic osteoclasts have several abnormalities includ- ...

The Molecular Biology of Paget S Disease 2014, Springer

ISBN-13: 9783662225073

Softcover Reprint of the Origi edition

Trade paperback