Targeted Drug Strategies for Cancer and Inflammation

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Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the ...

Targeted Drug Strategies for Cancer and Inflammation 2014, Springer

ISBN-13: 9781489988867

2011 edition

Trade paperback

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Targeted Drug Strategies for Cancer and Inflammation 2011, Springer-Verlag New York Inc., New York, NY

ISBN-13: 9781441984166

2011 edition

Hardcover

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