Transforming growth factor-ss (TGF-ss) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-ss now is rather well understood. Continuing revelations in the mechanisms of action of TGF-ss provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse ...

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