Statistical Methods for Cgh Array Analysis


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Genomic DNA copy number alterations are key genetic events in the initiation and progression of human cancers. Recent advance in the technique of microarray comparative genomic hybridization (array CGH) enables one to screen genome-wide for all possible regions with DNA copy number alterations, such as chromosome gains and losses, or localized amplifications and deletions. In this book, we introduce two statistical methods addressing two different questions for the data analysis of array CGH. The first method---Cluster ...

Statistical Methods for Cgh Array Analysis 2010, VDM Verlag, Saarbrucken

ISBN-13: 9783639114065

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