Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit- nessed a quantum leap in our knowledge, due to technological improve- ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno- type. Nevertheless, the recent progress in genetics will allow us to contem- plate, for ...
Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit- nessed a quantum leap in our knowledge, due to technological improve- ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno- type. Nevertheless, the recent progress in genetics will allow us to contem- plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop- mental biology. The purpose of the present book is to provide an overview that syn- thesizes up-to-date information on selected aspects of mouse brain devel- opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
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Very Good Ex-Library Condition. 8vo-over 7¾"-9¾" tall 339 pgs. Covers: from spontaneous to induced neurological mutations; mapping genes that modulate mouse brain development; genetic interactions during hindbrain segmentation in the mouse embryo; neurogenetic compartments of the mouse diencephalon and some characteristic gene expression patterns; neuronogenesis and the early events of the neocortical histogenesis; programmed cell death in mouse brain development; neurotrophic factors; growth factor invfluences on the production amd migration of cortical neurons; signalling from tyrosine kinases in the developing neurons and glia of the mammalian brain; the role of the p35/cdk5 kinase in cortical development; the reelin-signaling pathway and mouse cortical development; the subpial granular layer in the developing cerebral cortex of rodents; development of thalamocortical projections in normal and mutant mice; subject index. Green boards. Usual library markings. Clean and tightly bound. One corner is lightly bumped.
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