Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation

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In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity ...

Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation 2014, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Berlin

ISBN-13: 9783642438929

2012 edition

Paperback

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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation 2011, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Berlin

ISBN-13: 9783642246319

2012 edition

Hardcover

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