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This book examines the revolutionary new technology of gene targeting, from its history to its potential application for the genetic treatment of human diseases. It begins with an introduction to the field and a description of the whole gene targeting spectrum. It continues with discussions in the following areas: The molecular mechanisms of the homologous recombination reactions lying behind gene targeting technology The application of gene targeting approaches to the problems of tripanosomatide biology and ...

Gene Targeting 1994, CRC Press, Boca Raton, FL

ISBN-13: 9780849389504