As nucleophiles, simple alkenes are typically so unreactive that only highly active electrophiles, such as carbocations, peroxides, and halogens will react with them. For the generation of carbon-carbon bonds, milder methods will often be required. Fortunately, it is possible to increase the reactivity of alkene-type p-nucleophiles by introducing electron-donating substituents. Substitution of one H with an OH or OR gives an enol or a vinyl ether, which are already much better nucleophiles. Using nitrogen instead of oxygen, ...

Asymmetric Organocatalysis 2012, Springer

ISBN-13: 9783642262791

2009 edition

Trade paperback

Asymmetric Organocatalysis 2010, Springer

ISBN-13: 9783642028144