A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics ...
Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long--term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine. This new text provides a concise, user- ...
The topics focused on evaluation of impact of xenobiotics in the whole Urban Water Cycle are an interdisciplinary task which has a rising concern these days. Xenobiotics includes both inorganic elements like heavy metals, metalloids and man-made organic compounds such as pesticides, surfactants, solvents, fragrances, flavors, and pharmaceuticals ...
Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to:oPredict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in ...
This book offers a definitive, single source of information on PBPK modeling. Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access ...
This book describes the physiological and anatomical principles and the chemical and physical factors that determine uptake, translocation, accumulation, loss, and metabolism of anthropogenic chemicals in plants. Expert authors in the fields of biology, chemistry, ecology, environmental physics, and biochemistry provide recently developed methods ...
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include: enzyme function in the metabolism and ...
Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial, and regulatory areas of pharmacology and toxicology. This monograph, for the first time, has brought together researchers who deal specifically with drug-metabolizing ...
Leading textbook in biochemical toxicology. Addresses dose-response relationships; metabolism; toxic responses, and provides detailed examples to illustrate mechanisms of toxicity.
Highlights advances in the understanding of the biosynthesis of xenobiotic conjugates in mammals, fish, insects, and plants. Describes current methods for the isolation and identification of xenobiotic conjugates. Provides evidence for and implications of newly discovered novel xenobiotic conjugates and the biological significance and consequences ...
This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic ...
The extensive use of nitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to a large number of these agents under widely varying conditions. Before elimination the xenobiotics usually undergo biotransformation. Oxidative attack at nitrogen centres can affect detoxification, but equally well can induce ...
Xenobiotics (foreign chemicals) are natural or synthetic substances (such as pesticides) that cannot be utilized by plants in their energy-yielding metabolism. The main enzymatic reactions used by plants for xenobiotic detoxification include oxidation, reduction, hydrolysis, and conjugation with glutathione, sugars and amino acids. Xenobiotic ...
This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, ...
This is the timely title assembling the combined knowledge of some of the leading authorities in the field of small fish reproduction - an important topic for risk assessment and registration of chemical, agricultural, and pharmaceutical compounds. It provides guidance on the microscopic structure of living tissue and evaluation of the ...
Honey Bees: Estimating the Environmental Impact of Chemicals is an updated account of the different strategies for assessing the ecotoxicity of xenobiotics against these social insects, which play a key role in both ecology and agriculture. In addition to the classical acute laboratory test, semi-field cage tests and full field funnel tests, new ...
Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation ...
In the continuing fight against organic environmental xenobiotics, the initial success attributed to bioremediation has paled, in part due to the low availability of xenobiotics entrapped within a soil or sediment matrix. This has generated a very significant wave of interest in the bioavailability issue. However, much experimental evidence is ...
In recent years, there has been an alarming increase in environmental by-products that may be harmful to ovarian function. Along with this dangerous situation, the modern trend toward delaying motherhood poses immediate concerns regarding the long-term impact of environmental risks on human fertility. The uncertainty of our reproductive future ...
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, ...
The effects of man-made substances (xenobiotics) on the natural environment are described in this volume. It explains why these effects need to be understood, monitored and curtailed, especially in developing countries.
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are ...
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Foye's Principles of Medicinal Chemistry
by
David A Williams, Thomas L Lemke (Contributions by), William O Foye
