This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. It discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other ...
Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by ...
Leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental techniques to assess the physical characteristics and biological effects of superantigens. Their protocols range from those for investigating the interactions of superantigens with cellular receptors ...
This is the most comprehensive book on superantigen biology written to date. It uniquely combines many aspects of superantigen biology from the basic molecular mechanisms of superantigen action to the clinical consequences of superantigen intoxication, superantigen related diseases, and measures to combat superantigen toxicity.
Superantigens are microbial products that defy the conventional notion of lymphocyte activation to produce an unusually vigorous, genetically unrestricted response among many subsets of antigen-specific T cells. Bacterial toxins and certain viral gene products behave as superantigens, deleting T cells in vivo and stimulating their proliferation in ...
This text focuses on three major aspects of bacterial superantigens. Firstly, it describes their crystal structure and characteristics; one chapter describes recent data on crystal structure of superantigens complexed with their receptor, the MHC class II molecule. Secondly, the book deals with the function and effects on the immune system of ...
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