The rapidly evolving field of protein science has now come to realize the ubiquity and importance of protein-protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of high ...
This volume, part of the "Protein Reviews" book series, will successfully and clearly examine how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It will deal with the methodology behind the research and how to synergistically incorporate several methodologies for use. The study of complex systems ...
As more genetic and biochemical information about the protein components of cells accumulates, the analysis of protein-protein interactions is becoming increasingly important. This manual presents a wide range of techniques for identifying and analyzing these interactions, starting with standard molecular and biochemical techniques, and ...
This is an updated edition of a manual that provides a thorough collection of the technical and theoretical issues involved in the study of protein associations, including standard methods, biophysical approaches, and, in a final section, a collection of computational methods for integrating and analyzing interactions.
The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. "Prediction of Protein Structures, Functions and Interactions" presents a ...
A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein protein ...
The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse and present numerous challenges to modern biomolecular research because of their complexity. Analysis of patterns and principles governing these interactions has prompted a rapid development of computational methods to ...
The authoritative guide to analyzing protein interactions by mass spectrometry. Mass spectrometry (MS) is playing an increasingly important role in the study of protein interactions. "Mass Spectrometry of Protein Interactions" presents timely and definitive discussions of the diverse range of approaches for studying protein interactions by mass ...
The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with ...
This book presents a wide variety of mass spectrometry methods used to explore structural mechanisms, protein dynamics and interactions between proteins. Preliminary chapters cover mass spectrometry methods for examining proteins and are then followed by chapters devoted to presenting very practical, how-to methods in a detailed way. This book ...
Methods for detecting protein-protein interactions (PPIs) have given researchers a global picture of protein interactions on a genomic scale. "Biological Data Mining in Protein Interaction Networks" explains bioinformatic methods for predicting PPIs, as well as data mining methods to mine or analyze various protein interaction networks. A defining ...
A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and ...
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