This text analyzes the molecular mechanisms, chemical behaviour and regulation of iron transport in biological systems and offers novel methods for the assessment of iron transport across biological membranes. It details the characteristics and consequences of iron deficiency and excess to prevent diseases affecting major organ structures and ...
The objective of this book is to review and summarize recent developments in our understanding of iron transport and storage in living systems. It includes an overview of the evolutionary aspects of iron metabolism and bacterial iron transport, as well as a detailed discussion of molecules with specific roles in iron metabolism in higher organisms ...
Protein targeting is the study of how proteins synthesized in one part of the cell reach their ultimate destination. A cell may have to guide a protein through several membranes into one of its organelles, or take up or secrete a protein through its cell wall. This book is a preview of the latest research in this area, which has applications for ...
This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. ...
This work contains proceedings of the 32nd scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) in Bari, Italy, August 21-26, 2004.
Providing contributions drawn from experts' specialties of medicine, medical microbiology, pharmacology, therapeutics, medical oncology, infectious disease, biochemistry, molecular biology, and cell biology, this book explores drug transport and its role in resistance in antimicrobial and cancer chemotherapy. The book establishes the biochemical ...
In recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign material. This book provides an integrated approach to ...
"Nuclear Import and Export in Plants and Animals" provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of ...
Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
This volume covers all aspects of oxygen delivery to tissue, including blood flow and its regulation, as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This ...
The primary goal of this book is to explore the physical properties of polymers in confined spaces at the nanometer scale, with a particular emphasis on determining the mechanisms by which polymers are transported through narrow interstices. A variety of pore structures that polymers can penetrate have recently been discovered, and it is now ...
This volume contains state-of-the art- reviews dealing with diverse aspects of the sodium-hydrogen exchange family of membrane transporters - from basic science to clinical relevance. It includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical and covers established and emerging concepts related ...
In this second edition, the authors summarize the current state of the field including recent reevaluations of earlier studies of CPP mechanism. Beginning with an overview of classes of peptides and their individual uptake mechanisms, the text then covers the use of CPPs in gene modulation, and the targeting of specific tumors and other tissues - ...
In recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign material. This book provides an integrated approach to ...
This volume provides the latest research on oxygen transport to tissue. Ninety chapters cover varying aspects, including: oxygen carriers; oxygen transport in organs - brain, heart and lung; skeletal muscle; and abdominal muscles as well as systemic oxygenation in normal and disease states; oxygen transport in tumors; theoretical models and ...
The 30th scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) was held at the Western Conference Centre, UMIST, Manchester, in August 2002. It was attended by some 96 delegates and accompanying persons and there were 128 presentations.
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing ...
"Alkali Cation Transport Systems in Prokaryotes" is the first book that brings together the physiological, structural, and molecular biological aspects of the transport of sodium, potassium, and ammonium across the bacterial cell membrane. Sodium translocation plays a major role in energy coupling of some prokaryotes, and much of the book is ...
Over the last few years remarkable progress has been accomplished with respect to our understanding of nuclear structure and trafficking. This volume concentrates on aspects that involve or are of relevance to RNA and RNPs. Topics include fundamental advances and current problems in the structural organization of different subnuclear compartments: ...
A volume in the Molecular and Cellular Neurobiology series. This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. ...
Taken from the 25th Annual Meeting to the International Society on Oxygen Transport to Tissue He, this book covers such topics as molecular and genetic techniques to study oxygen transport in health and disease, and physiological mechanisms of oxygen sensing.
In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the ...
Written by acknowledge leaders in this field, this book not only fills a 40 year gap in the literature, but presents a markedly changed field with new approaches, outlooks, and findings. After discussing the chemistry of ions in solution, membrane transporters, and cellular ion and volume regulation, the book is organized around various animal ...
Thirteen chapters by industrial and academic authorities in this rapidly evolving field present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. This book's highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.
Calcium and comparable cations are fast being recognized for their role as vital components of animal physiology. When trying to answer questions such as why salmon can adjust to life in fresh water as well as seawater, or why chilli peppers taste hot to humans but evoke little response from chickens, we often find the answers lie in patterns of ...
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