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Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids
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Richard Durbin, Sean Eddy, Anders Krogh
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, ...
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Gene Cloning and DNA Analysis: An Introduction
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by
Terence A Brown
Known world-wide as the standard introductory text to this important and exciting area, the fifth edition of "Gene Cloning and DNA Analysis" addresses new and growing areas of research whilst retaining the philosophy of the previous editions. Assuming the reader has little prior knowledge of the subject its importance, the principles of the ...
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Probability Models for DNA Sequence Evolution
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by
Richard Durrett
Our basic question is: given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications ...
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Perl for Exploring DNA
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Mark D LeBlanc, Betsey Dexter Dyer
This book presents Perl programming with a uniquely interdisciplinary perspective for the bioinformatics classroom. The co-authors are a professor of computer science and a professor of biology who collaborate in developing software for DNA sequence analysis. A specialty of the authors is encouraging interdisciplinary undergraduate research. The ...
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Bioinformatics: Sequence and Genome Analysis
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by
David W Mount
The application of computational methods to DNA and protein science is an exciting development in biology. "Bioinformatics: Sequence and Genome Analysis" is a comprehensive introduction to this emerging field of study. The book has many valuable features. It is written for biologists who want to understand methods of sequence and structure ...
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Principles of Gene Manipulation
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Sandy B Primrose, Richard Twyman, Bob Old
Now in its sixth edition, Principles of Gene Manipulation provides an excellent introduction to the area of genetic engineering of plants, animals and microbes for advanced level undergraduates, with a basic understanding of genetics. This classic textbook has been substantially updated and revised to reflect the rapid advances that have been made ...
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Guide to Human Genome Computing
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Martin Bishop (Editor)
The "Guide to Human Genome Computing" is invaluable to scientists who wish to make use of the powerful computing tools now available to assist them in the field of human genome analysis. This book clearly explains access and use of sequence databases, and presents the various computer packages used to analyze DNA sequences, measure linkage ...
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DNA Sequencing: Optimizing the Process and Analysis
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Jan Kieleczawa
This in-depth new volume covers important topics in the field, including: biochemical and technological advances induced by Human Genome Project: proven and newly emerging methods of preparing DNA templates; effects of some widely used lab. reagents on DNA sequencing.
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Problems and Solutions in Biological Sequence Analysis
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by
Mark Borodovsky, Svetlana Ekisheva
This book is the first of its kind to provide a large collection of bioinformatics problems with accompanying solutions. Notably, the problem set includes all of the problems offered in Biological Sequence Analysis (BSA), by Durbin et al., widely adopted as a required text for bioinformatics courses at leading universities worldwide. Although many ...
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DNA Sequencing II: Optimizing Preparation and Cleanup
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Jan Kieleczawa
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Protein Sequencing Protocols
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American Bar Association, Bryan John Smith (Editor)
Bryan John Smith updates his much-acclaimed first edition with new and updated techniques for determining the sequence of proteins and peptides. This edition includes not only novel approaches to the validation of quality assurance methods, reflecting the current importance of biopharmaceuticals, but also offers a guide to analysis of protein ...
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Sequence analysis primer
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Michael Ray Gribskov, Ph.D. (Editor), John Devereux, Ph.D. (Editor)
Computerized sequence analysis is an integral part of biotechnological research, yet many biologists have received no formal training in this important technology. Sequence Analysis Primer offers the necessary background to enter this exploding field and helps more seasoned researchers to fine-tune their approach. Compatible with most sequence ...
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Pyrosequencing Protocols
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Sharon Marsh
"Pyrosequencing Protocols" presents detailed protocols for the multidisciplinary application of Pyrosequencing technology, all written by world-renowned experts in the field. This comprehensive volume enables quick reference by collecting the primary applications for Pyrosequencing, and supplementing each protocol with troubleshooting tips ...
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Nonisotopic Probing, Blotting, and Sequencing
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Larry J Kricka (Editor)
Since the publication of "Nonistopic DNA Probe Techniques" in 1992, the move away from radioactive materials for research and diagnostics has continued. This is due in part to public awareness of the hazards of radioactive waste and laws making radioactive disposal more difficult and costly and to improvement in both the sensitivity and ...
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DNA Sequencing
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by
Luke Alphey
The technique of DNA Sequencing lies at the heart of modern molecular biology. Since current methods were first introduced, sequence databases have grown exponentially, and are now an indispensable research tool. This up-to-date, practical guide is unique in covering all aspects of the methodology of DNA sequencing, as well as sequence analysis. ...
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Comparative Genomics, Volume 1
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by
Nicholas H Bergman (Editor)
Comparative Genomics, Volume 1, provides a collection of robust protocols for molecular biologists beginning to use comparative genomic analysis tools in a variety of areas. Volume I contains the first four of seven sections. In the first section, the reader is introduced to genomes via a number of visualization tools that allow one to browse ...
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Mass Spectrometry and Genomic Analysis
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by
J Nicholas Housby
The human genome project is set to revolutionise health care and medicine in the near future. The genetic make up of each individual gives clues as to the genetic factors that predispose one to a particular genetic disease. Single Nucleotide Polymorphisms (SNPs), single base changes in the nucleotide DNA sequence of individuals, are thought to be ...
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Genomics: The Science and Technology Behind the Human Genome Project
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Charles R Cantor, Cassandra L Smith
A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology--from two top researchers In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human ...
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Computer Analysis of Sequence Data Part II
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by
Annette M Griffin, Hugh G Griffin
These comprehensive, up-to-date handbooks are designed for those scientists engaged in the computer analysis of sequence data who want hands-on help in using the most important commercial software available, but simply do not have the time to become computer experts. The expert authors guide you through the programs with easy-to-follow, step-by ...
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Comparative Genomics, Volume 2
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Nicholas H Bergman (Editor)
Comparative Genomics, Volume 2, provides a collection of robust protocols for molecular biologists beginning to use comparative genomic analysis tools in a variety of areas. Volume 2 contains the last three of seven sections. In the second volume, the fifth section describes a number of tools for comparative analysis of domain and gene families. ...
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Theoretical and Experimental DNA Computation
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Martyn Amos
This book provides a broad overview of the entire field of DNA computation, tracing its history and development. It contains detailed descriptions of all major theoretical models and experimental results to date, which are lacking in existing texts, and discusses potential future developments. It also provides a useful reference source for ...
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Nonisotoic Probing, Blotting, and Sequencing
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by
Larry J Kricka (Editor)
Since the publication of "Nonistopic DNA Probe Techniques" in 1992, the move away from radioactive materials for research and diagnostics has continued. This is due in part to public awareness of the hazards of radioactive waste and laws making radioactive disposal more difficult and costly and to improvement in both the sensitivity and ...
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Automated DNA Sequencing and Analysis
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Mark D Adams (Editor), J Craig Venter (Editor), Chris Fields (Editor)
A timely book for DNA researchers, "Automated DNA Sequencing and Analysis" reviews and assesses the state of the art of automated DNA sequence analysis - from the construction of clone libraries to the development of laboratory and community databases. It presents the methodologies and strategies of automated DNA sequence analysis in a way that ...
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High Performance Computational Methods for Biological Sequence Analysis
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by
Tieng K Yap, Ophir Frieder, Robert L Martino
"High Performance Computational Methods for Biological Sequence Analysis" presents biological sequence analysis using an interdisciplinary approach that integrates biological, mathematical and computational concepts. These concepts are presented so that computer scientists and biomedical scientists can obtain the necessary background for ...
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Analytical Techniques in DNA Sequencing
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by
Brian K Nunnally (Editor)
While one marvels at the DNA generated by the Human Genome Project, perhaps just as significant and fascinating is the development of the amazing analytical technology that has permitted us entry into the genomic era and a whole new level of scientific understanding. "Analytical Techniques in DNA Sequencing" takes a look at the various DNA ...
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