Offering the most current and complete coverage of nucleoside analog activity in oncology and hematology, this single-source volume includes topics from pharmacology to previously unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases, such as chronic lymphocytic and hairy cell ...
This third of four volumes continues the work of its well-received predecessors by providing comprehensive articles on specific lines of research. All volumes are written with medicinal chemists, organic chemists, physical chemists, and biological chemists in mind. Additionally, with the spate of recent research on the anticancer, antiviral, and ...
A comprehensive survey of established and experimental methods in nucleoside synthesis This volume presents a comprehensive review of nucleoside synthesis with a uniquely broad perspective. It describes the three principal types of nucleoside-forming reactions the fusion reaction, the metal salt procedure, and the Hilbert-Johnson reaction as well ...
Interest in chemical entities capable of blocking or modifying cell metabolism ultimately goes back to the discovery of the structure of DNA in the 1950s. Understanding of the biochemical processes involved in cell metabolism rapidly led to the idea that compounds could be designed which might interfere with these processes, and thus could be used ...
This work presents an up-to-date review on the chemistry and biology of nucleosides. It covers modern synthetic methodology. It provides comprehensive coverage of antiviral nucleosides. This book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral ...
This text on the silyl method for the synthesis of nucleosides originated as a modification of the classical method and uncovers one of the basic methods for the preparation of nucleosides and their analogues. The synthesis of nucleosides is an essential feature in research programmes concerned with anti-cancer chemistry and in other areas of ...
The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside- and nucleotide-based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress ...
This study reviews the instances in which nucleotides and their derivatives are excreted in the medium during cultivation of microorganisms, with emphasis on the production of commercially important nucleotides, IMP and GMP. Other nucleotides prepared by fermentation such as adenine, adenosine, ATP, NAD, CoA and cAMP are also discussed.
This handbook describes methods of preparation, characterization, toxicity, and therapeutic indices of transition metal complexes of the naturally occurring heterocyclic nucleobases and their derivatives. Modes of coordination are listed together with the relevant spectral data and major methods of investigation. Where appropriate, the spectrum of ...
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