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Frontiers in Molecular Toxicology
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Lawrence J Marnett (Editor)
Provides concise, up-to-date articles highlighting the most recent advances in mechanisms of toxicology and the methods for studying them. Examines chemical approaches to the solution of toxicologically interesting problems. Originally published in Chemical Research in Toxicology, the articles convey the opportunity and excitement that exists at ...
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Biomolecular Free Radical Toxicity: Causes and Prevention
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Helen Wiseman, Peter Goldfarb, Tim Ridgway
Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book ...
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PCR Protocols in Molecular Toxicology
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John P Vanden Heuvel, Ph.D. (Editor), John P Vanden Heuvel (Editor)
Molecular toxicology is an emerging discipline that utilizes molecular and cell biology to understand how drugs and chemicals result in their unwanted effects.PCR Protocols in Molecular Toxicology is a practical guide to the use of polymerase chain reaction (PCR) to help examine, on a molecular and cellular level, how toxic responses are ...
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Applications of Molecular Biology in Environmental Chemistry
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Minear A Minear, Roger A Minear (Editor), Lawrence L Needham (Editor)
During this century we have experienced a shift in the leading causes of death from infectious diseases, such as pneumonia and influenza, to chronic diseases, such as heart disease and cancer. Whereas infectious diseases are often related to a single infectious agent, chronic diseases are often related to a combination of environmental (including ...
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Molecular and Cellular Methods in Developmental Toxicology
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George P Daston (Editor)
This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic ...
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Toxicant-Receptor Interactions: Modulations of Signal Transduction and Gene Expression
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Michael S Denison (Editor), William G Helferich (Editor)
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are ...
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Molecular and Cellular Mechanisms of Toxicity
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Francesco De Matteis (Editor), Lewis L Smith (Editor)
Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The ...
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Molecular Toxicology Protocols
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Phouthone Keohavong
The text brings together a series of works, each applying the most commonly used methods to elucidate specific molecular aspects of toxicology. Molecular Toxicology Protocols is divided into four parts, each describing the application of methods to study a specific aspect of toxicology. Part I describes applications and methods to analyze products ...
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Molecular Toxicology
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by
P David Josephy, Bengt Mannervik, David Josephy
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressiong, and analysis of enzymes of biotransformation; and molecular toxicology of aromatic amines, nirosamines, ...
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Biological membranes in toxicology
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by
Ernest Foulkes
Using this concise yet complete introduction to all aspects of biological membranes and their responses to toxicants, the reader will understand the role of cell membranes in controlling uptake, distribution, extrusion and excretion of toxic xenobiotics. The book also covers the historical background and critically evaluates some of the ...
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Molecular Mechanisms of Metal Toxicity and Carcinogenesis
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by
Xianglin Shi, Vince Castranova, Val Vallyathan
Since the 1980s, chemical and cellular studies have contributed enormously to our understanding of metal-induced carcinogenesis, and many hypotheses on the role of metals in pathophysiological processes have been investigated. The conference on "Molecular Mechanisms of Metal Toxicity and Carcinogenesis" in September 2000 focused on the latest ...
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Biological Concepts and Techniques in Toxicology: An Integrated Approach
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by
Jim E Riviere, DVM, Ph.D (Editor)
Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of ...
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Predicting Chemical Toxicity and Fate
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by
Cronin
Quantitative Structure-Activity Relationships (QSARs) are increasingly used to predict the harmful effects of chemicals to humans and the environment. The increased use of these methods in a variety of areas (academic, industrial, regulatory) results from a realization that very little toxicological or fate data is available on the vast amount of ...
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Molecular Toxicology
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by
David Josephy, P David Josephy
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames ...
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A Guide to Molecular Pharmacology-Toxicology,
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Robert M. Featherstone
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Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets
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by
Richard A Barrios, Urs Boelsterli, Boelsterli A Boelsterli
Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important tool for human risk assessment. Mechanistic Toxicology is a timely textbook that provides an introduction to this important, but often neglected, ...
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Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets
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by
Urs A Boelsterli
A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics ...
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Molecular Neurotoxicology: Environmental Agents and Transcription-Transduction Coupling
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by
Nasser H Zawia (Editor)
While the number of target genes and products studied following neurotoxicant exposure has been abundant, little attention has been given to the mechanisms involved in signal transcription-transduction coupling. Until now, no book has been published on the actions of environmental agents on the brain with a specific focus on transcriptional ...
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Molecular Biology of the Toxic Response
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Alvaro Puga (Editor), Kendall Wallace (Editor)
Encouraging the incorporation of molecular biology techniques into the experimental approach to various toxicological problems, the format of the book is two-staged. Each chapter first introduces how various molecular techniques can be successfully applied to solving a specific toxicology question and proceeds to describe the techniques themselves ...
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Apoptosis in Toxicology
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by
Ruth Roberts, Gerry Cohen (Foreword by)
Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the ...
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Aquatic Toxicology Molecular Biochemical and Cellular Perspective
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by
Donald C Malins (Editor), Gary K Ostrander (Editor)
"Aquatic Toxicology" examines findings from research on the chronic effects of pollutants on aquatic species. Understanding these chronic effects is vital to determining the impact of small concentrations of pollutants on aquatic life in rivers, estuaries, lakes, and coastal waters. Featuring research from experts in the field, this book evaluates ...
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Molecular Responses to Xenobiotics
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by
S. Parvez
Based upon the most advanced tools and concepts developed in modern biology, this work on molecular toxicity provides clear insight into the xenobiotic target(s), activity and mechanism of action, and reveals the detailed response and fate of the cell. It is therefore the most reliable assessment of toxic risks, particularly in the long term, ...
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Molecular aspects of toxicology
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by
D. E. Hathway
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Selectivity and Molecular Mechanisms of Toxicity
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by
Francesco De Matteis
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Advances in Molecular Toxicology
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by
C Reiss (Editor), S Parvez (Editor), G Labbe (Editor)
This volume presents a collection of invited papers from the First European Workshop on Molecular Toxicology, held in Sophia Antipolis, France. It covers eight selected topics in molecular toxicology. The first two are devoted to "physics", dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in ...
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