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Chemoattractant Ligands and Their Receptors
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Richard Horuk (Editor)
Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it ...
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The chemistry of macrocyclic ligand complexes
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by
Leonard F Lindoy
This book contains an overview of complex formation by macrocyclic ligand systems. The study of macrocyclic chemistry represents a major area of activity which impinges on a range of other areas in both chemistry and biochemistry. The field has characteristically yielded many interesting and unusual compounds. The text discusses the structures and ...
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Receptors and Ligands in Neurological Disorders
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Professor Amartya K Sen, Tyrone Lee (Editor)
This book summarises current studies which involve receptors and ligands in neurological disorders. The advance in the study of receptors in general enables investigators to explore the mechanism of action of psychotropic drugs and to minimise their side effects. It will lead to the study of molecular events and an understanding of the nature and ...
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Computational and Structural Approaches to Drug Discovery: Ligand-Protein Interactions
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Robert M Stroud (Editor), Janet Finer-Moore (Editor)
Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials...This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug ...
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Fragment-Based Drug Discovery: A Practical Approach
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Edward R Zartler (Editor), Michael J Shapiro (Editor)
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole ...
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Metal-Ligand Interactions Molecular-, Nano-, Micro-Systems in Complex Environments
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Malgorzata Witko (Editor), Nino Russo (Editor), Dennis R Salahub (Editor)
The emphasis in this book is on problems related to crossing the boundary from molecular systems to nano, macro and micro-scale materials and to the effects of the environment on the properties of the molecular systems. The following fields are discussed: metal clusters; inorganic complexes and materials; surface phenomena; adsorption and ...
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Chemical Thermodynamics of Compounds and Complexes of U, NP, Pu, Am, Tc, Se, Ni, and Zr, with Selected Organic Ligands
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by
Wolfgang Hummel
This volume is part of the series on "Chemical Thermodynamics," published under the aegis of the OECD Nuclear Energy Agency. It contains a critical review of the literature on thermodynamic data for compounds of complexes of oxalate, citrate, EDTA and iso-saccharinate with uranium, neptunium, plutonium, americium, technetium, selenium, nickel and ...
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Receptor - Based Drug Design
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Paul Leff (Editor)
Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. Explains the experimental and theoretical methods used to characterize interactions ...
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Protein-Ligand Interactions: Structure and Spectroscopy
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Stephen E Harding (Editor), Babur Z Chowdhry (Editor)
The two Practical Approach volumes on protein-ligand interaction do not comprise a comprehensive compilation of all the methods that can be used to investigate protein-ligand interactions. Instead, they are a selection of the most useful and easily applied methods and will be an invaluable guide to the principal techniques used to study the ...
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Protein'ligand Interactions: Methods and Applications
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by
G Ulrich Nienhaus (Editor)
This work is a readily reproducible collection of established and emerging techniques for studying the interaction between proteins and ligands, including biochemical/bulk techniques, structure analysis, spectroscopy, single-molecule studies, and theoretical/computational tools. Among the highlights are surface plasmon resonance (SPR) and ...
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Peripheral Benzodiazepine Receptors
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by
Giesen-Crouse
"Neuroscience Perspectives" provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular ...
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Chiral Diazaligands for Asymmetric Synthesis
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by
Marc Lemaire
The use of phosphine derivatives has historically induced the tremendous development of catalysis (both non-asymmetric and asymmetric). Although the chemistry of amines is more documented, the use of nitrogen-containing ligands only appeared recently. Nevertheless, during the last ten years, the results describing chiral diamine preparations and ...
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Protein-Ligand Interactions: A Practical Approach Volume 2: Structure and Spectroscopy
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by
Stephen E Harding (Editor), Babur Z Chowdhry (Editor)
The two Practical Approach volumes on protein-ligand interaction do not comprise a comprehensive compilation of all the methods that can be used to investigate protein-ligand interactions. Instead, they are a selection of the most useful and easily applied methods and will be an invaluable guide to the principal techniques used to study the ...
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Ferrocenes: Ligands, Materials and Biomolecules
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by
Petr Stepnicka (Editor)
Ferrocene - the prototypical metallocene - is a fascinating molecule. Even though it was first discovered over fifty years ago, research into ferrocene-containing compounds continues apace, largely stimulated by their successful applications in catalysis, materials science and bioorganometallic chemistry. Ferrocene derivatives are now recognised ...
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Organofluorine Chemistry
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by
Professor Kenji Uneyama
The replacement of hydrogen with fluorine in organic molecules can profoundly influence their chemical and physical properties, leading to a range of compounds with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, so that organofluorine chemistry is economically ...
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Inorganic Biochemistry: Research Progress
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Jason G Hughes (Editor), Alton J Robinson (Editor)
Inorganic biochemistry is an emerging subject and interdisciplinary field between inorganic chemistry and biochemistry. The task of inorganic biochemistry is to research the interaction between the metal complex (or metal ion) with biological ligand at the molecular level. There exists wide research about inorganic biochemistry such as biological ...
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Catalytic Aspects of Metal Phosphine Complexes: Based on a Symposium Sponsored by the Acs and CIC Divisions of Inorganic Chemistry at the 1980 Biennia
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Elmer C. Alyea (Editor), Chemical Institute of Canada, Devon W. Meek (Editor)
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Metal-Ligand Interactions: Structure and Reactivity
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by
Nino Russo
This work emphasizes the experimental determination of structure and dynamics, supported by the theoretical and computational approaches needed to establish the concepts and guide the experiments. Leading experts present masterly surveys of: clusters, inorganic complexes, surfaces, catalysis, ab initio theory, density functional theory, ...
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Biometals and Ligands for Anticancer Drug Design: Molecular Mechanisms of Superoxide Dimutase Models Antitumor Effects
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by
Gennadifi Efremovich Zaikov, E A Pavfernov, E A Parfenov
Contents: Introduction; The Search for Antitumour Agents Among Complex Copper Compounds; SOD Models as Anticarcinogens; Resemblance and Differences of SOD Models and Enzymes. Probable Functions of SOD Models in Biological Systems; Cytotoxic Activity of SOD Models; Mechanisms of Physiological Compatibility of SOD Models 1 -- The Role of Ligand ...
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Atlas of Metal-Ligand Equilibria in Aqueous Solution
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J Kragten
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Structure-Based Ligand Design
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by
R Mannold, Hans-Joachim Bvhm, Raimund Mannhold
Although emerging only since the 1980s, structure-based drug design has already become a powerful tool for commercial drug design. Much has been learned, however, since the first attempts to develop drugs on the basis of available biochemical and structural data. This volume, besides presenting the underlying principles and foundations of the ...
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Immobilized Affinity Ligand Techniques
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by
Hermanson, Mallia, Smith
This book is a practical guide to the preparation and use of immobilized affinity ligands for purification, catalysis, and analysis. Special emphasis is given to immunochemical techniques including antibody isolation, preparation of antibody fragments using immobilized enzymes, and immunoaffinity chromatography. The book provides easy-to-follow, ...
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Protein-Ligand Interactions: A Practical Approach 2 Volume-Set
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by
Stephen E Harding (Editor), Babur Z Chowdhry (Editor)
A ligand is an atom, molecule or ion that can bind to a specific site on a protein. The interactions between any protein and its ligands are essential for the protein to function properly. The first of these two volumes covers the principal hydrodynamic and calorimetric techniques for studying protein-ligand interactions. The second volume covers ...
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Central & Peripheral 5-Ht3 Receptors
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by
Michel Hamon (Editor)
This text offers an extensive overview of the present knowledge of 5-HT3 receptors in the central nervous system and the periphery with regard to their exclusive location on neurones and their pharmacological, biochemical and functional properties. Among its 12 chapters, 5 are devoted to the present and potential use of 5-HT3 ligands in the ...
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Complex Formation and Stereochemistry of Coordination Compounds
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by
Buslaev
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