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Killer Cell Dynamics: Mathematical and Computational Approaches to Immunology
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Dominik Wodarz
This book reviews how mathematics can be used in combination with biological data in order to improve understanding of how the immune system works. This is illustrated largely in the context of viral infections. Mathematical models allow scientists to capture complex biological interactions in a clear mathematical language and to follow them to ...
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Killer Lymphocytes
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by
Gideon Berke, William R Clark
We have known about the existence of killer lymphocytes since 1960, when they were discovered in connection with transplant rejection in vivo. Since then, we have uncovered at least five subsets of lymphocytes that can kill other cells in vitro, establishing the study of cell-mediated cytotoxicity (CMC) as a major field of immunological inquiry. ...
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Current Topics in Innate Immunity
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J D Lambris (Editor)
Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way, to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly ...
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Natural Killer Cell Protocols: Cellular and Molecular Methods
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by
Kerry S Campbell (Editor)
Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific ...
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Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods
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by
Michail Sitkovsky, P a Henkart (Editor)
This collection of papers from researchers of cytotoxic cells provides a state-of-the-art review of this field. Special chapters cover the mechanisms of lethal hit delivery and immuno-pharmacological manipulations of cytotoxic cells.
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Current Topics in Microbiology and Immunology Specificity, Function and Development of NK Cells: NK Cells: The Effector Arm of Innate Immunity
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by
K Karre, M Colonna
In recent years understanding of natural killer cells has increased. Using information from research, this text provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells and their biological role in controlling infections and tumours.
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Natural Killer T-Cells: Roles, Interactions, and Interventions
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by
Nathan V Fournier
Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self and foreign lipids and glycolipids. Upon activation, NK T cells are able to produce large quantities ...
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Natural Immunity to Normal Hemopoietic Cells
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by
Rolstad M D Rolstad, Bent Rolstad, Rolstad Bent Ed
"Natural Immunity to Normal Hemopoietic Cells" presents the first comprehensive compilation of experimental systems, theories, and views of the mechanisms behind NK cell recognition of normal hemopoietic cells. Leading scientists in the field have contributed chapters covering the role of Major Histocompatibility Complex (MHC) class I antigen ...
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Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease
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by
Alexander Sigalov (Editor)
Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoetic system and function to transduce signals leading to a variety of biologic responses. These receptors share common structural features, including extracellular ligand-binding domains and intracellular signaling ...
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NK Cell Mediated Cytotoxicity: Receptors, Signaling, and Mechanisms
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by
Lotzova Lotzova, Eva Lotzova
This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. This book will be an excellent learning tool and ...
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NK Cells and Other Natural Effector Cells
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by
Ronald B Herberman
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The Role of Interleukin-2 in the Treatment of Cancer Patients
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by
John Wagstaff
Recombinant human interleukin-2 became available for clinical use in the mid 1980s. Recent years have seen an enormous amount of clinical research with this cytokine and interleukin-2 has now been registered for use in a number of European countries for the treatment of metastatic renal cell carcinoma. This book is designed to provide the clinical ...
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Molecular Basis of NK Cell Recognition and Function
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by
Lorenzo Moretta
Only in recent years have the molecular mechanisms of natural killer cells been understood. This text is an updated review of the signal transduction and functions of NK cells, and their roles in transplantation, anti-tumour response and infectious diseases.
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Cytotoxic T cells : biology and relevance to disease
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by
Jack R. Battisto, Janet Plate, Gene M. Shearer, New York Academy of Sciences
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Natural Killer Cells: Biology and Clinical Application
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Reinhold E. Schmidt
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The Natural Killer Cell: The Natural Immune System
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by
Claire E Lewis (Editor), James O'd McGee (Editor)
The ability of an organism to combat infection by foreign particles and microbial pathogens is essential for its survival and evolutionary success. Such efforts at immunity can take two forms. A considerable number of works have been published which focus on the central role of antigen recognition and antibody structure and function in the host ...
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Mechanisms Cytotoxity NK Cells
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by
Ronald B Herberman
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Cytotoxic Cells: Basic Mechanisms and Medical Applications
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by
Michail V. Sitkovsky (Editor), Pierre Henkart (Editor)
This volume synthesizes recent groundbreaking advances in our knowledge of the molecular mechanisms, biological roles, and medical applications of cytotoxic lymphocytes. Leading investigators examine current concepts on the recognition of antigen by T-cell receptors; the molecules mediating target recognition by natural killer cells; the ...
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Cytolytic Lymphocyte Complement
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Eckhard Ed Podack, Eckhard R Podack
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Lymphohaematopoietic Growth Factors in Cancer Therapy
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Mertelsmann R Ed, Roland Mertelsmann
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NK Cells in the Liver
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by
Luc Bouwens
This is a presentation of reviews and research data on the biology of natural killer (NK) cells in the liver. It gives methods for the isolation and characterization of these cells from rodent and human liver. Their ultrastructure and phenotype are described with many illustrations. It is demonstrated that NK cells are heterogeneous and that the ...
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Lymphohaematopoietic Growth Factors in Cancer Therapy
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by
Roland Mertelsmann
Recent experimental and clinical progress in the evaluation of cytokines in treatment concepts for cancer patients is the central theme of this book in the "ESO Monographs" series. The discussion revolves around the experimental basis as well as current clinical experience with the use of human recombinant cytokines. It gives the state of the art ...
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Immunobiology of Natural Killer Cells
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Lotzvoa/Herberm
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Natural Killer Cells and Host Defense
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Carlos Lopez, Edwin W. Ades (Editor)
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Cytotoxic T Cells in HIV and Other Retroviral Infections
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by
Paul Racz, Norman L. Letvin
Cytotoxic T lymphocytes play a central role in containing the spread of the AIDS virus (HIV) as well as other retroviruses. This publication provides a broad overview of our current understanding of this immune response in the HIV-infected patient. With contributions from major laboratories throughout the world, the effector T lymphocyte response ...
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