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Guide to Drug Development: A Comprehensive Review and Assessment
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Bert Spilker
Written by one of the foremost authorities on clinical trials, drug development, and regulatory affairs, "Guide to Drug Development" is a comprehensive review of the principles and activities involved in developing new drugs, devices, and other medical products. The book covers many topics not discussed in any other textbook and includes timely ...
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Drug-Like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization
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Edward H Kerns, Li Di
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates ...
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FDA Regulatory Affairs: A Guide for Prescription Drugs, Medical Devices, and Biologics
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Douglas J Pisano (Editor), David S Mantus (Editor)
Since the enactment of the first drug law in 1848, the legislation surrounding drug development has evolved into a maze of regulations that can be hard to navigate. Not only are existing regulations constantly reviewed and updated, the increasingly rapid rate of development in the pharmaceuticals field creates new issues that need to be addressed ...
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Drugs: From Discovery to Approval
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by
Rick Ng
'Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs' - "Doody's Reviews", May 2009. 'The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a ...
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Career Opportunities in Biotechnology and Drug Development
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Toby Freedman
As the world of biotechnology has grown in leaps and bounds, so too have the career opportunities. But the choices can be daunting. What types of jobs are available? How do you get your foot in the door? What will your job entail if you become a Preclinical Project Manager or a Process Scientist ? What's the difference between biotech and ...
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From Bench to Market: The Evolution of Chemical Synthesis
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Walter Cabri, Romano Di Fabio
Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery ...
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Silent Warning
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by
Kathleen Long
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Miracle Medicines: Seven Lifesaving Drugs and the People Who Created Them
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by
Robert L Shook
Veteran journalist Shook goes behind the scenes to tell the fascinating stories of seven recent breakthrough drugs as well as those individuals who discover, test, and bring these drugs to the public. He also offers a new perspective on the often-maligned pharmaceutical companies.
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Bioinformatics and Drug Discovery
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by
Richard S Larson (Editor)
This book is a collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and ...
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Drug Discovery and Design
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by
Edward M Scolnick (Editor), Frederic M Richards (Editor), David S Eisenberg (Editor)
Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of ...
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Handbook of Anticancer Drug Development
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by
Daniel R Budman (Editor), Alan Hilary Calvert (Editor), Eric Keith Rowinsky (Editor)
Written by leading investigators from academia and the pharmaceutical industry, this volume is a comprehensive, practical guide for all researchers involved in anticancer drug development. The book covers the entire field from preclinical research, through clinical trials, to licensure requirements in the United States and in the European Union. ...
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Drug Development
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Timothy S Gaginella, Ph.D. (Editor), Antonio Guglietta, M.D., Ph.D. (Editor)
Timothy Gaginella and Antonio Guglietta bring together hands-on experts to critically review the many promising new areas of gastrointestinal pharmacology at the molecular level. Key chapters discuss such major themes as cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways in the gut, and the influence of cytokines on ...
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High Throughput Screening: Methods and Protocols
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William P Janzen (Editor)
In the years since the release of the popular first edition, the field of High Throughput Screening (HTS) has evolved considerably, from a small niche area of study to a major, essential scientific technique. In "High Throughput Screening: Methods and Protocols, Second Edition", experts in the field fully update the previous edition to best serve ...
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Statistical Issues in Drug Development
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by
Stephen Senn
Drug development is the process of finding and producing therapeutically useful pharmaceuticals, turning them into safe and effective medicine, and producing reliable information regarding the appropriate dosage and dosing intervals. With regulatory authorities demanding increasingly higher standards in such developments, statistics has become an ...
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Computational and Structural Approaches to Drug Discovery: Ligand-Protein Interactions
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by
Robert M Stroud (Editor), Janet Finer-Moore (Editor)
Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials...This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug ...
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Fragment-Based Drug Discovery: A Practical Approach
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Edward R Zartler (Editor), Michael J Shapiro (Editor)
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole ...
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Pharmacogenomics in Drug Discovery and Development
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by
Qing Yan
Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art ...
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Biomarker Methods in Drug Discovery and Development
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Feng Wang (Editor)
Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In "Biomarker Methods in Drug Discovery and Development", expert researchers provide a tool box for those who have a general interest in biomarker research and for those ...
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Drug Discovery: From Bedside to Wall Street
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by
Tamas Bartfai, Graham V Lees
Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs work medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why ...
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Drug Discovery and Development: Volume 1: Drug Discovery
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by
Mukund S Chorghade (Editor)
This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. It includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). It discusses the discovery of ...
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Biopharmaceutics Applications in Drug Development
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by
Rajesh Krishna (Editor), Lawrence Yu (Editor)
Drug performance is a vital aspect of new drug development as it draws on interdisciplinary expertise from both pharmaceutics and pharmacokinetics disciplines. It is at the key interface that the discipline of biopharmaceutics has emerged. The past two decades have witnessed considerable advances in biopharmaceutics, particularly with regard to ...
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Drug Discovery and Development
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by
Mukund S Chorghade (Editor)
This two-volume set provides a full account of the entire sequence of drug development, from conceptualizing the drug, creating a library of candidates, and conducting clinical trials, to optimizing the synthetic route, marketing the drug, and developing delivery methods. Comprehensive in scope, the set bridges the gap between medicinal and ...
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Pharmaceutical Innovation: Revolutionizing Human Health
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by
Ralph Lardau, Basil Achilladelis, Alexander Scriabine
A wide-ranging look at an industry that is central to the health and welfare of humanity, this pioneering work documents how science has provided an astonishing array of medicines for coping with human ailments over the last 150 years. "Pharmaceutical Innovation" covers the history of the pharmaceutical industry and its many contributions to human ...
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New Drug Discovery and Development
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by
Daniel Lednicer
A case history approach to drug synthesis and discovery, this book helps you discover the origins of some of today's most popular drug therapies. You can explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for ...
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Handbook of Assay Development in Drug Discovery
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by
Lisa K Minor (Editor), Minor K Minor
The need to screen targets faster and more efficiently, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the increasing use of multiwell assays for drug discovery. The Handbook of Assay Development in Drug Discovery is a reference that describes the complete armament of tools currently available for performing ...
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