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Computational Genetics and Genomics: Tools for Understanding Disease
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Gary Peltz (Editor)
Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses ...
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Human Risk Assessment: The Role of Animal Selection and Extrapolation
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Raymond Bonnett, Roloff V Roloff, M V Roloff (Editor)
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Toxin-Induced Models of Neurological Disorders
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Woodruff, Nonneman
This is the first evaluative discussion of the use of neurotoxins to produce animal models of Alzheimer's, Parkinson's, Huntington's and other human neurodegenerative diseases. The work also responds to criticisms of the use of animals in biomedical research by examining the utility, validity, and limitations of the models presented. An excellent ...
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How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis
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Herrathow Von Herrathow, Matthias Von Herrath (Editor), Bart O Roep (Editor)
Our understanding of the genetics and pathophysiology of animal models for autoimmune diseases such as type 1 diabetes and multiple sclerosis has increased significantly in the past few years. The central themes of this volume are the necessity for novel and improved models, the optimal use of information from animal models to understand ...
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Advances in Swine in Biomedical Research, Volume 1
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Mike E Tumbleson, L B Schook (Editor)
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What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice
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Jacqueline N Crawley
Dr. Jacqueline N. Crawley, author of the First and Second Editions of "What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice", continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what's wrong with my mouse? Turn to "What's Wrong with My Mouse?" to discover ...
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Cell Death and Diseases of the Nervous System
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Rajiv R Ratan (Editor), Vassilis E Koliatsos (Editor)
Written by pioneers in the field, this book captures all the important classic and new research on neuronal injury and cell death and the application of these results to the treatment of a wide range of neurological and neuropsychiatric illness. The outcome is a unique integration of cellular and molecular insights, clinical knowledge, and ...
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Behavioral Models in Stress Research
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by
Allan V Kalueff
Stress is an adaptive response that has developed throughout evolution, and is associated with multiple changes in the biochemistry, histology and physiology of an organism. As stress may induce or contribute to multiple neuropsychiatric disorders, the rigorous investigation of the neural substrates of stress has become a critical endeavour of ...
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The Laboratory Primate
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Sonia Wolfe-Coote
A volume in the "Handbook of Experimental Animals" series, "The Laboratory Primate" details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. The practical information on regulatory requirements, not available in other texts, is ...
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A Handbook of Mouse Models of Cardiovascular Disease
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Qingbo Xu (Editor)
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator's ability to manipulate the mice surgically. Many mouse models require ...
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Transgenic and Knockout Models of Neuropsychiatric Disorders
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by
Gene S Fisch
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and ...
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CRC Handbook of Animal Models of Pulmonary Disease, Volume II
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by
Jerome Owen Cantor, Pearl (Contributions by), Susan Goodman (Contributions by)
This two-volume handbook provides important information concerning the development, implementation, evaluation, uses, advantages, and limitations of a wide variety of animal model of pulmonary disease. While the work focuses on stepwise procedures for inducing and quantifying disease, additional emphasis is placed on each model's relationship to ...
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Mouse Models of Human Cancer
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Eric C Holland (Editor)
Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, ...
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Drosophila: A Toolbox for the Study of Neurodegenerative Disease
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Amritpal Mudher (Editor), Tracey A Newman (Editor)
"Drosophila "gives an overview of the ways in which Drosophila is currently being used as a model organism to further our understanding of a spectrum of human neurological diseases. Each chapter is written by respected researchers and gives an excellent account of the subject that is suitable for postgraduate and postdoctoral researchers.
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Animal Models in Psychiatry, II
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by
Alan A Boulton (Editor), Mathew J Martin-Iverson (Editor), Glen B Baker (Editor)
The wealth of material presented in Animal Models in Psychiatry has necessitated its expansion into a comprehensive, two-volume work. This second volume - the companion to Neuromethods 18 - continues the presentation of the latest methodologies for the use of animal models in psychiatric research. Contributors are renowned experts in their ...
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Antithrombotic Drugs in Thrombosis Models
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by
Josef Hladovec
"Antithrombotic Drugs in Thrombosis Models" presents a critical review of the use of thrombosis models and an original, highly sensitive methodology for testing antithrombotics based on a more adequate understanding of thrombotic processes. The methods form an integrated system stressing particularly the plurifactorial and global character of ...
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In Vivo Models of Inflammation
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Douglas W Morgan
This text presents a further addition to the "Progress in Inflammation Research" series.
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Aging and Postraumatic Stress Disorder
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Paul E Ruskin (Editor), John A Talbott, M.D. (Editor)
Aging and Posttraumatic Stress Disorder (PTSD) explores the psychological sequelae of severe trauma in elderly patients and the manifestations in old age of psychological symptoms secondary to trauma experienced earlier in life. Although methodological issues have made the scientific study of PTSD difficult, a number of well-designed research ...
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Animal Models of Cognitive Impairment
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Edward D Levin (Editor), Jerry J Buccafusco (Editor)
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, "Animal Models of Cognitive Impairment" ...
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The Role of the Chimpanzee in Research
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by
G Eder
Beginning with an examination of the political, scientific and ethical issues involved in primate research, this volume provides detailed information on the breeding and care of chimpanzees in captive populations. The role of the chimpanzee in biomedical research is then reviewed. Emphasis is placed on research into infectious diseases, particular ...
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Animal Models of Neurological Disease
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by
Boulton, Baker 1947-, Butterworth
The use of animal models continues to be the most reliable way of studying pathophysiologic mechanisms as well as treatments for neurological disorders. In two companion volumes, Animal Models of Neurological Disease highlights new information and techniques available in this rapidly growing area. This volume of Neuromethods - the second of a two ...
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Tumor Necrosis Factor: Methods and Protocols
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by
Angelo Corti (Editor), Pietro Ghezzi (Editor)
This is a comprehensive collection of readily reproducible techniques for TNF production, characterization, mutagenesis, and detection in biological specimens. Also included are several in vitro assays and animal models for studying the role of TNF in various TNF-related diseases and in cancer. The collection offers molecular and cellular ...
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Sourcebook of Models for Biomedical Research
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by
P Michael Conn, Ph.D.
The collection of systems represented in the Sourcebook of Models for Biomedical Research reflect the diversity and utility of models that are used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. Some models have the ...
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Ocular Toxicology
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Ingo Weisse, Keith Green (Editor), O Hockwin (Editor)
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Research Progress in Alzheimer's Disease and Dementia, V.3
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by
Miao-Kun Sun (Editor)
Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is ...
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