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A Means to an End: The Biological Basis of Aging and Death
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William R Clark
In this scholarly, yet accessible work, a scientist provides a description of the aging process at the cellular level, and discusses research on the relationship between genetics and longevity.
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Sex and the Origins of Death
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William R Clark
Death, for bacteria, is not inevitable. Protect a bacterium from predators, and provide it with adequate food and space to grow, and it would continue living--and reproducing asexually--forever. But a paramecium (a slightly more advanced single-cell organism), under the same ideal conditions, would stop dividing after about 200 generations--and ...
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Apoptosis: The Life and Death of Cells
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Christopher Potten, James Wilson
The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between ...
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Apoptosis Techniques and Protocols
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Andrea C LeBlanc, Andra C LeBlanc (Editor)
In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, ...
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Combination Cancer Therapy: Modulators and Potentiators
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Gary K Schwartz (Editor)
Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies ...
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Aging of the Genome: The Dual Role of DNA in Life and Death
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Jan Vijg
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of ...
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Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification
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Myrtle A Davis (Editor)
Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for ...
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Apoptosis: The Molecular Biology of Programmed Cell Death
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Michael F Jacobson, PH.D. (Editor), Nicola McCarthy (Editor)
Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost ...
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Apoptosis, Senescence, and Cancer
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David A Gewirtz (Editor), Shawn Edan Holt (Editor), Steven Grant (Editor)
"Apoptosis, Senescence and Cancer" provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for ...
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Apoptosis in Neurobiology
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Yusuf A Hannun (Editor), Yusef A Hannun, Rose-Mary Boustany
The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death - has created an urgent need for reliable documentation of the different approaches to and methods of studying the various aspects of the field. "Apoptosis in Neurobiology" is an important resource for researchers in this emerging frontier of biomedical study. This ...
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Apoptosis, Genomic Integrity, and Cancer
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Julien L Van Lancker
This book introduces readers to the molecules involved in apoptosis and genomal integrity and considers the gain or loss of the functions that lead to cancer.
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Mechanisms of Lymphocyte Activation and Immune Regulation VI
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Sudhir Gupta (Editor), J John Cohen (Editor)
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Programmed Cell Death
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Yun Bo Shi (Editor), David W Scott (Editor), Yufang Shi (Editor)
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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response
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Hans E Kaiser
The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to ...
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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 2
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Rakesh Srivastava (Editor)
The aim of "Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume Two", is to provide recent developments in cell survival and apoptotic pathways and their involvement in human diseases such as cancers and neurodegenerative disorders. It contains thirty one chapters which have been divided into four sections: Malignant ...
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When Cells Die: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death
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Richard A Lockshin (Editor), Zhara Zakeri (Editor), Jonathan Tilly (Editor)
This is an integrated and cross-disciplinary presentation of cell death research. It emphasises the pervasiveness of the phenomena and its importance in development, homeostasis, aging and disease. Encompassing the phenomena from genetics to signal transduction and observed manifestation, and presenting the work through model systems of life-forms ...
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Poly(adp-Ribosyl)Ation
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Alexander Ba1/4rkle, Alexander B]rkle (Editor), Alexander Burkle (Editor)
Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.
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Apoptosis
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Enrico Mihich (Editor), Robert T Schimke (Editor)
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Apoptosis and Cancer Chemotherapy
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John A Hickman (Editor), Caroline Dive (Editor)
This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It reviews the profusion of new signaling, modulating, and ...
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Apoptosis Genes
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James J Wilson, Christopher S Potten (Editor), James W Wilson (Editor)
Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Research over the last decade is now enabling scientists to comprehend how genes and the protein products interact ...
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Cell Death During HIV Infection
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Andrew D Badley (Editor)
Although immune-based therapies have been the primary focus in the battle to arrest HIV, researchers now are considering the implications of apoptosis dysregulation during HIV-induced immunodeficiency. Mounting evidence indicates that cell death is not a passive process, but rather one that is tightly coordinated and regulated. This opens the door ...
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Programmed Cell Death, Volume I: Cellular and Molecular Mechanisms
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Mark P Mattson, Steven Estus, Vivek Rangnekar
Apoptosis, or programmed cell death, is an adaptive form of cell death that plays a critical role in turnover of mitotic cells and various tissues in the adult, including epithelial cells, fibroblasts and various endocrine cells. Programmed cell death also plays a major role in development in organizing the body plan and molding intricate cellular ...
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Apoptosis and Cancer: Methods and Protocols
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Gil Mar, Ayesha Alvero (Editor), Gil Mor (Editor)
Our understanding of the apoptotic pathway and its regulation has improved significantly in the last 10 years. However, as our knowledge of the intricate intracellular events increase, we realize the complexity of the regulatory mechanisms that control it. As such, "Apoptosis and Cancer" describes the performance of contemporary techniques for ...
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Signal Transduction Pathways, Part C: Cell Signaling in Health and Disease
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Marc Diederich (Editor)
This third volume to emerge from the cell signaling meeting in Luxembourg (see Part A and Part B) focuses on the therapeutic potential for targeting cell signaling mechanisms with particular attention to cancer therapies and inflammatory signaling pathways as well as immunomodulation.
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The Neurology of Neuroblastoma
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by
Nina Felice Schor
Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65 per cent of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only ...
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