Purinergic receptors are a type of neuroreceptor which has been found to have unique therapeutic potential as a chemical compound in the treatment of many neurological disorders such as Alzheimer's disease, chronic pain, Parkinson's disease, stroke, thrombosis, bladder function, stress, and cancer. This book covers the molecular pharmacology, ...
Michael Williams' comprehensive new survey volume of Adenosine and Adenosine Receptors highlights the phenomenal progress made during the last decade in understanding the roles of adenosine and related purines in tissue function. It also focuses on receptor subtypes and the search for selective ligands and the development of radioligand binding ...
This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist ...
This volume disseminates the most recent advances in understanding of the molecular structure, transport mechanism, and regulatory properties of the sodium/potassium adenosine triphosphatase. Recent knowledge gained from other transport ATPases is incorporated as well. The volume also provides contributions from crystallographers, ...
After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the ...
This book provides valuable information for investigators interested in the signaling and regulatory functions of adenosine and the adenine nucleotides. Topics covered in this comprehensive volume include the historical development of research on adenosine and adenosine triphosphate; various aspects of the formation, metabolism, release, transport ...
The potent biological actions of the purine nucleotides and nucleosides, adenosine and ATP, have been recognized since 1929, and the clinical effects in humans of administration of ATP have been explored since the 1950s. However, it was not until 1972 that purinergic neurotransmission was proposed, and later, in 1978, the existence of specific ...
Used extensively in cellular and molecular biology research and cytogenetic applications, nucleotide analogs are currently available for the treatment of various diseases. "Nucleoside Triphosphate and Their Analogs: Chemistry, Biotechnology, and Biological Applications" features the contributions of 18 scientists from both academia and industry in ...
This text contains a selection of lectures given during the 5th International Symposium on Adenosine and Adenine Nucleotides, recently held in Philadelphia, Pennsylvania. It covers a wide range of subjects from molecular and cellular biology to clinical applications. Emphasis has been placed on cutting edge information derived from studies using ...
The growth in the number of articles on adenosine cardioprotection in the late-1990s has been related in large part to the hypothesis that adenosine plays a role in ischemic preconditioning. Ischemic preconditioning is the phenomenon in which a brief period of ischemia (and reperfusion) prior to a more prolonged occlusion reduces myocardial ...
Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. This volume focuses on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological ...
This volume disseminates the most recent advances in understanding of the molecular structure, transport mechanism, and regulatory properties of the sodium/potassium adenosine triphosphatase. Recent knowledge gained from other transport ATPases is incorporated as well. The volume also provides contributions from crystallographers, ...
This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10--14, 1997. The Symposium was hosted by ...
In 1997, J.C. Skou was awarded the Nobel Prize in Chemistry for his discovery of Na/K-ATPase, which has led to widespread appreciation of this enzyme in the scientific community. This volume contains findings and insights in the field. It includes a proposal that Na/K-ATPase plays a role as a tranducer of signal transduction, and, amongst other ...
This book provides a broad view of the current research activities in adenosine and adenine nucleotide research, with contributions from many leading experts in the field. Like the three previous Symposia, the 4th International Symposium on "Adenosine" was designed to integrate the recent advances made in the rapidly expanding field of adenosine ...
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