Over its lifespan so far, this annual series has traced the state of the art of vaccination from empiricism to molecular design. In this work, the investigation of immunogens at a structural level is especially prominent, as is further exploration of DNA immunization.
This volume encompasses human and simian immunodeficiency viruses and other viruses, bacteria and parasites. Induction of responses by mucosal routes, DNA immunization and the use of recombinant antibodies receive particular prominence. The book surveys the concepts in vaccine development.
Considerable research effort has been devoted to the prevention and therapy of AIDS using approaches which have been successful against infection with other viral or microbial agents, ie, active and passive immunization. This effort is impeded by the high variability of the HIV envelope glycoproteins, the major target for immunotherapy. This ...
Well over half of the 58 papers from the September 1993 annual conference on new vaccines (presumably at Cold Springs Harbor) discuss AIDS; the rest cover immunology, gene vaccination, and bacteriology. Among the specific topics are recombinant viral vaccines expressing cytokine genes, polynucleotid
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