Contributors from European and US universities and corporations review recent developments in the integration of downstream processing and bioconversion, describing their experience with many separation technologies, including some still in the experimental stage.
Expanded bed adsorption chromatography is a novel processing technique for the purification of biomolecules, combining clarification, concentration and initial purification in one step. By such an integration it is possible to reduce the number of steps in the purification process, to shorten the processing time and to improve the yields. The ...
Smart polymers are macromolecules capable of undergoing rapid, reversible phase transitions from a hydrophilic to a hydrophobic microstructure when triggered by small changes in their immediate environment, such as slight variations in temperature, pH or ionic strength. Until now, it has always been considered that polymers are passive ...
Smart polymers have an extensive range of applications in the biotechnology and biomedical industries. Although polymers have always been considered passive participants, the second edition of "Smart Polymers: Applications in Biotechnology and Biomedicine" promotes a more active role for smart polymers within the process of bioseparation than ...
This publication details the isolation of proteins from biological materials, techniques for solid-liquid separation, concentration, crystallization, chromatography, scale-up, process monitoring, and product formulation, and regulatory and commercial considerations in protein production. The authors discuss release of protein from biological host, ...
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