'... Holmes book will profoundly affect historians' views of Lavoiser's methods and achievements, of the nature of the Chemical Revolution, and more broadly, of the methodologies appropriate to the history of science.' --Evan M. Melhado, 'Isis'
This is the first volume of the definitive biography of Hans Krebs, one of the world's foremost biochemists. It begins with the early work of Krebs in Germany, where, working with Otto Warburg, he discovered the urea cycle in 1932. This early achievement, coupled with the discovery of the citric acid cycle, are viewed as the foundations upon which ...
This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various ...
From the days of the alchemists through the creation of the modern laboratory, chemistry has been defined by its instruments and experimental techniques. Historians, however, have tended to focus on the course of chemical theory rather than on the tools and experiments that drove the theory. This volume moves chemical instruments and experiments ...
Disease, disaster and disability plagued the Stuart Family during the period they ruled England - 1603 to 1714. Dementia in James I, the beheading of Charles I, acute mercury poisoning in Charles II, a nosebleed in James II, acute hemorrhagic smallpox in Mary II, and lupus erythematosus in Queen Anne took them 'off the throne', one by one. ...
A fascinating and detailed chronicle, "Reconceptualizing the Gene" relates how, between 1954 and 1961, the biologist Seymour Benzer mapped the fine structure of the rII region of the genome of the bacterial virus known as phage T4. Benzer's accomplishments and discoveries are widely recognized as a tipping point in mid-twentieth-century molecular ...
This comprehensive volume completes Frederic Holmes's notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs's research notebooks as well ...
In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that ...
Whether conceived of as "research groups", "knowledge factories" or "invisible colleges", the research schools examined in this volume are observed in the historical and cultural contexts of their disciplines, their institutional settings, their national traditions and scientific styles. Given its broad overview, the volume raises questions about ...
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