Disorders that affect tissue differentiation, organogenesis, and morphogenesis constitute a significant proportion of human hereditary diseases. Until very recently, however, their genetic causes and pathogenesis have been unknown. Now, with the elucidation of the molecular pathways that govern developmental processes and with advances in gene ...
This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. In The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models, Charles J. Epstein concerns himself with how and ...
Presents a series of papers reporting on recent progress in understanding key genetic, molecular and cellular mechanisms behind differentiation and morphogenesis associated with trisomy 21. Also offers an examination of the condition's physical phenotype and its anatomical manifestations.
Produced in association with the National Down Syndrome Society, this book reviews the current status of Down syndrome research and examines future directions in the field.
Any lawyer confronted with international litigation should turn to this practical resource with relief - and complete confidence. In looseleaf format to ensure up-to-date reliability, "International Litigation" guides the practitioner step by step through the international litigation process, revealing the advantages and forewarning of the ...
Over the last decade, biomedical researchers have documented that individuals with Downs syndrome have a markedly high probability of developing Alzheimer disease in later life. This book presents a comprehensive overview of current research efforts aimed at understanding the behavioural, neuropathological, and genetic correlations between Downs ...
As a detailed discussion of approaches to understanding the genetics and the underlying mechanisms of the different phenotypic characteristics of Down syndrome, this title also includes animal models of human chromosone 21 relevant to the phenotypic mapping of Down syndrome. Since the precedents for phenotypic mapping go far beyond human ...
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