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Group Sequential Methods

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Group Sequential Methods with Applications to Clinical Trials describe s group sequential stopping rules designed to reduce average study len gth and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group se quential tests, and explain how to choose the most appropriate test an d interim analysis schedule. Their topics include placebo-controlled r andomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and ...

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